WOMAC is delighted to report that we have now fulfilled our pledge to EHE Rare Cancer Charity (UK) and we have received this note from Hugh Leonard, Chair of the Trustees, explaining how the money will be used.
WOMAC’s wonderful funding support for the EHE Rare Cancer Charity will be used to help fund an exciting new PhD research project being undertaken at the Department of Developmental Biology and Medicine at the University of Manchester. The project will address key aspects of the biology of epithelioid haemangioendothelioma (EHE), the ultra-rare sarcoma that the charity is fighting.
In particular, the Principal Investigator, Dr Valerie Kouskoff, and her team are hoping to address key questions relating to how the fusion protein that drives tumour growth in EHE affects endothelial cells (cells that line your blood vessels) where EHE tumours occur. The project will set out to address the following key questions:
How does fusion protein expression affect the biological characteristics of endothelial cells?
How does fusion protein expression modify the transcriptional landscape of endothelial cells?
Can fusion protein-expressing endothelial cells provide viable cell lines and models of EHE?
Dr Kouskoff also hopes to create induced pluripotent stem cells using patient-donated tumour cells. If successful, these pluripotent stem cells will represent a unique and powerful approach to study the biology of EHE. The project only started in early 2019, but already some interesting results have been seen, opening up new avenues for investigation. The charity hopes that this project may ultimately answer some fundamental questions about EHE, and help lead to new drug regimens and other therapeutic options.
Hugh Leonard, Chair of Trustees, said: “We are very excited about this project which is being led by one of the UK’s recognised endothelial cell specialists. But this project is only possible because of the unbelievably generous support of groups like WOMAC. We could not be more grateful for the support we have received, and thank every single person who participated to make WOMAC’s donation possible. We look forward to updating the WOMAC team as the project progresses.”
About EHE Rare Cancer Charity
Epithelioid Haemangioendothelioma (EHE) is a very rare form of vascular sarcoma. The EHE Race Cancer Charity (EHERCC) gathers vital data from its worldwide membership of EHE patients, which is invaluable to the medical and research scientists who are working to understand and treat this rare cancer. The EHERCC’s key objectives are to support patients wherever they are in the world; to promote, fund and direct research into EHE; and to act as advocates for greater awareness of, and care for, EHE.
Women on the Move Against Cancer is a group of female volunteers working in the automotive industry. It was established in 1979 and aims to continue the fight against cancer by supporting a variety of projects, searching for more effective treatments or improving the quality of life for cancer sufferers, their families and carers.